Name: Kisspeptin
SKU: 8160
Availability: InStock

Kisspeptin

$200.00

10 mg · Purity Exceeds 99% · For Research Only

A reproductive-axis neuropeptide for laboratory research into GnRH pulsatility, gonadotropin signaling, and limbic neuroendocrine pathways. Designed for in-vitro and animal-model investigations of HPG-axis biology, KISS1R receptor pharmacology, and metastasis-suppressor mechanisms.

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Overview

Overview
Kisspeptin is a neuropeptide encoded by the KISS1 gene, originally identified in 1996 as a melanoma metastasis suppressor and re-characterized in 2003 as the obligate ligand of the KISS1R / GPR54 receptor and the primary gatekeeper of pubertal GnRH activation. The decapeptide Kisspeptin-10 retains the C-terminal RFamide motif required for receptor binding and is the most widely used research form.

Across investigative literature, Kisspeptin has been studied for its role in GnRH neuron depolarization via Gq/11-PLC-IP₃ signaling, downstream LH and FSH release, and modulation of metabolic and circadian inputs to the hypothalamic-pituitary-gonadal axis. Investigators at Imperial College London have published a sustained series of clinical studies examining gonadotropin response, oocyte-maturation triggering in IVF models, and limbic-network activation by fMRI — representing some of the deepest human research available for any peptide in this category.

Specification

CAS Number	374675-21-5
Chemical Name	Kisspeptin-10 (Metastin 45-54)
Peptide Type	Synthetic decapeptide; KISS1R ligand
Sequence	H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Molecular Formula	C₆₃H₈₃N₁₇O₁₄
Molecular Weight	1302.5 g/mol
Physical Appearance	White lyophilized powder
Purity	≥99% (HPLC & Mass Spectrometry verified)
Verification Method	HPLC & MS
Container	Sterile sealed glass vial
Solubility	Soluble in sterile or bacteriostatic water
Storage Conditions	2–8 °C; protect from light; long-term −20 °C
Intended Use	Laboratory research use only (RUO)
COA Availability	Lot-specific COA provided per batch

Potential Research Applications
Potential Research Applications
Kisspeptin is one of the most clinically investigated peptides in the reproductive-neuroendocrinology category, with a published evidence base that spans cell culture, animal models, and human clinical investigations. It is commonly employed in studies that require precise activation of the HPG axis or interrogation of KISS1R signaling cascades.
- Reproductive-Axis Signaling Research — GnRH/LH/FSH pulsatility studies, KISS1R receptor pharmacology, and HPG-axis feedback models.
- KNDy Neuron Biology — Co-localization with neurokinin B and dynorphin in hypothalamic circuit models and pulse-generator investigations.
- Metabolic-Reproductive Integration — Kisspeptin response to leptin, insulin, and energy-status inputs across reproductive and metabolic phenotypes.
- Metastasis-Suppressor Research — KISS1 expression and downstream signaling in melanoma, breast, and gastric cell-line models.
FAQ

FAQ
✦ What is the difference between Kisspeptin-10 and Kisspeptin-54?

Kisspeptin-10 is the minimal active fragment sharing the C-terminal RFamide decapeptide required for KISS1R binding. Kisspeptin-54 (metastin) is the dominant endogenous circulating form. The decapeptide is commonly used in research for its well-characterized receptor pharmacology and simplified handling.

✦ Is human clinical research available for Kisspeptin?

Yes — Kisspeptin has one of the deeper human research profiles in this class. The Imperial College London group has published investigations on gonadotropin response, IVF oocyte-maturation triggering, and limbic brain activation by fMRI. Researchers should consult the primary literature for endpoint and safety details.

✦ What documentation comes with each order?

Every vial includes a lot-specific COA confirming identity, purity (≥99%), and composition. Full lot traceability accompanies every shipment.

✦ Who is eligible to purchase?

Kisspeptin is available to qualified purchasers conducting lawful laboratory or research-based work. By placing an order, buyers confirm they are experienced in handling RUO materials and will adhere to all applicable safety and regulatory protocols.

Research-Validated

TESTED

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TESTED

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Why Choose Sunday

Every product we ship is engineered to remove variables and let your data speak for itself.

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Prep

Flip the cap, swab the septum with 70 % IPA.

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Draw

Use a sterile syringe to withdraw the volume needed for peptide reconstitution

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Inject

Transfer the water into your peptide vial; swirl until dissolved.

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Store

Research peptides in a clean airlight vial in the fridge at around 36 to 46 degrees Fahreheit.

“Reliable solvents are the backbone of reliable science.”

Frequently Asked Questions

✧ 1. What are Sunday peptides used for?

All Sunday products are sold for research use only. They are not intended for human consumption, therapeutic, or diagnostic use. Our peptides are designed exclusively for controlled laboratory research, educational studies, or analytical testing. Every product label and supporting document clearly reflects this compliance standard.

✦ 2. Who is eligible to purchase peptides?

Purchases are available to verified professionals, licensed clinics, educational institutions, and qualified research entities. Individuals may also purchase peptides for legitimate research or educational purposes, but all buyers must acknowledge and agree to Sunday research-only terms prior to completing any order. We do not sell or endorse products for personal or medical use under any circumstance

♡ 3. How should peptides be handled and stored?

Peptides arrive as a lyophilized (freeze-dried) powder. For laboratory reconstitution, use only sterile bacteriostatic water or sterile saline (0.9 percent NaCl). Gently introduce the solvent and swirl—do not shake. Once reconstituted, store at 35°F to 45°F for short-term use, or at –4°F for long-term preservation. Protect vials from light and moisture, and avoid repeated freeze and thaw cycles to maintain stability.

⟡ 4. Why do peptide vials appear nearly empty?

Because peptides are measured in milligrams, the quantity often appears minimal or as a thin layer within the vial. This is completely normal for high-purity research peptides. Each vial undergoes precision weighing and purity testing using high-performance liquid chromatography (HPLC) and mass spectrometry to ensure the correct labeled amount is present.

✧ 5. What documentation and quality assurances come with each product?

Every peptide includes a Certificate of Analysis (COA) verifying its identity, purity (≥ 99 percent), and composition. Each batch is U.S. sourced and assembled under strict quality oversight and internal auditing. Full lot traceability, validated purity testing, and documentation accompany every shipment to ensure reproducibility, compliance, and scientific reliability.

Kisspeptin

Overview

Specification

Potential Research Applications

FAQ